North Syria stands out as a heavily urbanized region during the Hellenistic era, with many cities founded by the first Seleucid king evolving into major urban centres by the Roman period. However, our understanding of the early history and development of these cities is hindered by limited archaeological evidence, posing challenges in assessing their size, character, and evolution during the Seleucid rule. Additionally, the influence and role of indigenous peoples and traditions remain elusive. In this presentation, I will delve into the findings of recent fieldwork conducted in Doliche, situated on the outskirts of Gaziantep in South-East Turkey, to shed new light on the trajectories of urbanism in Seleucid North Syria. By examining the archaeological findings made since 2015, I hope to contribute to a deeper understanding of urban development in Seleucid and Post-Seleucid North Syria, unravelling the complex interplay between indigenous traditions, external influences, and evolving urban structures.